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Newest One is a dual-action injectable combining polynucleotides and hyaluronic acid. Backed by HPT™ technology, it targets hydration, tissue repair, and visible skin revitalisation—ideal for advanced skin rejuvenation protocols.
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Plinest One is a cutting-edge cosmetic treatment designed to rejuvenate and revitalise your skin. Leveraging the power of PDRN (Polydeoxyribonucleotide), a DNA-based ingredient extracted from salmon, Plinest One stimulates the skin's natural repair processes, promoting collagen production and enhancing elasticity.
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Plinest Fast polynucleotide gel for intradermal infiltration into the face, hands and scalp. The Plinest care line is a face and body regenerating anti-aging programme based on nucleotides, hyaluronic acid and vitamin E. Manufacturer Mastelli has been committed to developing specific products in the field of aesthetic medicine. Its revitalising line based on polynucleotides of natural origin and hyaluronic acid was designed specifically to moisturise the skin in depth, improving its firmness and suppleness in time.
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Plinest Newest is a variation that includes hyaluronic acid (HA). In short, the HA and Mannitol enhance hydration under the skin, give better lift and boost skin radiance for patients with dry and wrinkled skin. Like all Plinest range of products, at its core, Newest promotes bio-revitalisation to reverse signs of aging. The HA and Mannitol support the regeneration triggered by the polynucleotides by adding volume and moisture.
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Plinest Hair (1 x 2ml) deeply penetrates the scalp, providing essential nutrients that rejuvenate weak, thinning, or damaged hair. Its intensive formula not only aims to reduce hair loss but also stimulates new hair growth, resulting in a denser, more vibrant hair appearance. Ideal for those experiencing signs of hair aging or environmental damage, Plinest Hair offers a quick, convenient treatment to revitalize the scalp and restore hair to its natural vitality and shine.
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The original Plinest works as a powerful skin healing and rejuvenation booster. It is suitable for most skin across all age groups and gender. Once injected, the polynucleotides in Plinest trigger collagen production and fibroblast (a type of cell that contributes to skin healing), which makes your cells recover and restore naturally. Over time this increased fibroblast activity and collagen production accelerates skin repair, resulting in better skin radiance, youthful skin texture plus improved skin rigidity and elasticity. Suggested for prevention and maintaining younger patients’ skin quality. Highly purified polynucleotides (PN-HPT®) 20 mg/ml Available in 2ml syringe
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PLINEST Eye 1 x 2ml is a polynucleotide-based injectable gel and is specifically designed for the periorbital area and eye contour. It works on a cellular level to repair tissue and improve skin quality and texture from within. PLINEST Eye helps stimulate fibroblasts and encourages cell turnover, improving elasticity, boosting collagen production and providing hydrating properties to skin. Key indications include fine lines and superficial wrinkles, crow’s feet, dark under-eye circles, sagging areas, eye contour as well as upper eyelids, poor tone and skin texture around eyes.











